Eddie Morra (Bradley Cooper) is a writer who lives in New York City and has recently been dumped by his girlfriend Lindy (Abbie Cornish) in addition to failing to meet the deadline to turn in his new book, which he hasn't written yet. One day, Eddie comes across Vernon Grant (Johnny Whitworth), the brother of his ex-wife Melissa Grant (Anna Friel). Vernon is a drug dealer who offers Eddie a sample of a new drug, NZT-48, which will make him more focused. Eddie accepts and, much to his surprise, the drug increases his intelligence and improves his focus.
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